Clinical Basis

CenZiteK

Clinical Basis

Botkin 2006

Summary

Clinical investigations were conducted at the S.P. Botkin Hospital from May 20, 2006, to September 1, 2006, in order to evaluate the clinical application of the Electro Interstitial Scan (E.I.S), we performed drug administration studies.

Two hundred fifteen (215) test subjects (Age 54 + 16) were recorded with the EIS System. These patients presented affections diagnosed by supplementary and conventional examinations (hypothyroidism, hypertension, atherosclerosis or thrombosis risk, and Major depression) and were undergoing no treatment.

The recruitment criteria had been agreed upon before the tests began. The treatments corresponding to the diseases were decided by the conventional examinations results, and a follow-up being undertaken on one hand with the EIS System and on the other hand by conventional methods.

Hypotheses tested

The EIS can be used for the monitoring treatment?

The hypothesis was validated.

The EIS system seems accurate for the monitoring of the drugs’ monitoring of the considered diseases:

Hypothyroidism: Monitoring of the EIS system versus laboratory test (TSH) with the thyroid substitute treatment r2 = 0.79 P< 0.0001
High blood pressure: Monitoring of the EIS system versus NIBP measurement with the Beta blockers treatment r2 = 0.78 P< 0.0001 Monitoring of the EIS system versus NIBP measurement with CEI treatment r2 = 0.78 P< 0.0001
Atherosclerosis and/or thrombosis risk: Monitoring of the EIS system versus laboratory test (Prothrombin Time) with the anticoagulant treatment r2 = 0.91 P< 0.0001
Major depression: Monitoring of the EIS system versus the depression’s symptomatology with the SSRIs treatment r2 = 0.87 P< 0.0001

Full text PDF

Caudal 2007

Summary

Clinical trials were conducted at the office of Dr. Frederique Caudal, pediatrician and specialist in Attention-Deficit/Hyperactivity Disorder (ADHD) in children.

Symptoms of this disorder are related to a low level of cerebral neurotransmitters.

Variations in genes involved in the neurotransmitter systems are likely to mediate this delicate balance and have an effect on the function of these chemicals in the brain.

The diagnosis of ADHD children is almost symptomatic, which leads to the dramatic possibility of error and treatment (Ritalin®, or SSRI or catecholamine’s) with medications associated with numerous side effects in particular for the age of the population.

For this reason, a new, measurable, and therefore objective marker was proposed using the electro-medical system called the Electro Interstitial Scanner (EIS) in adjunct to the conventional diagnoses and treatment monitoring of the ADHD children.

From 10.04.2006 to 05.16.2007, data from 59 children (age 12 + 5) presenting symptoms and not undergoing treatment were recorded with the EIS System. This database was compared with another control group database (age 14 + 6) of non-hyperactive children also recorded with the same EIS System.

Hypothesis tested

The hypothesis tested was:

Can the EIS System with reference to its ESG (Electro Scan Gram) graph be used as a marker for ADHD children and therefore as adjunct to the conventional diagnosis of ADHD children?

This hypothesis was validated by statistical analysis.

It appeared, following statistical analysis of the said database (STATISTICA), that the ADHD ESG graph generated by the EIS System presented a specificity of 85% (CI calculated at 95%) and a sensitivity of 83% (CI calculated at 95%) when compared to a database of non-hyperactive children.

The volume 9/10 of the ESG graph of the group diagnosed was 14.7 +/- 5 10-6 S.m-1 and the non-ADHD children was 4.7 +/-2.7 10-6 S.m-1 (P<0.0001, and P<0.0001 respectively)

The volume 1/3/16/18 of the ESG graph of the group diagnosed was3.1 S.m-1+/- 0.6 and the non-ADHD children was 4.7 10-6 S.m-1+/- 0.7 (P<0.001, and P<0.001 respectively)

The volume 2/4/15/17 of the ESG graph of the group diagnosed was 10.6 +/- 710-6 S.m-1 and the non-ADHD children was 28+/- 8 10-6 S.m-1 (P<0.0001, and P<0.0001 respectively)

In light of the results, the ESG graph generated by the EIS System may be considered a marker for ADHD children and therefore as adjunct to the conventional diagnosis of ADHD children.

Full Text PDF

Enter supporting content here